Dr. Robert Bransfield, past president of ILADS, has accumulated a list of 700 articles citing chronic infection associated with tick-borne diseases.
Patients exposed to tick-borne diseases sometimes have the progressive development of increasing symptoms, even after different antibiotic treatments. All of these symptoms cannot be explained by the presence of other unrelated conditions that are comorbid with and/or mimic tick-borne diseases. Although most agree that many of the progressive symptoms are immune mediated, there are two opposing views on the further cause of the disease process.
One hypothesis is infection is no longer present and there is speculation that some unknown self-perpetuating mechanism causes the intensification of chronic symptoms seen in these patients. The other hypothesis proposes that infection can persist which can cause intensifications of symptoms by provoking the immune system and possibly by other additional mechanisms. The National Institute of Health recognizes many chronic diseases may eventually be proven to have an infectious basis and established the Human Microbiome Project which recognizes bacterial cells are ten times more prevalent than human cells in the human body. With time there are increasing peer reviewed medical journal articles supporting the position that persistent tick-borne infection occurs and can contribute to causing the intensification of chronic symptoms which creates a serious burden of disease globally.
Below are some peer reviewed journal articles providing evidence supporting this scientific position. The list contains over 700 articles and is divided into several different sections. The first section is a general list of articles supporting the evidence for persistent infection. The other sections support persistence as it pertains to psychiatric symptoms, dementia, autism, and congenital transmission. The list shall be periodically revised.