International Lyme And Associated Diseases Society
Leaders in Lyme Disease Education and Training

Speaker: Alan MacDonald, MD

Sunday, Nov. 4, 2012

International Dermatology and Molecular Dermatopathology of Lyme borreliosis

For the past 30 years Dr. Alan MacDonald has worked to revive the Model of Syphilis and draw attention to clinical and laboratory parallels between Treponema pallidum infection and Lyme Borreliosis. Dr. MacDonald hypothesized that Alzheimer's disease might be the late neural borreliosis equivalent of General paresis of the insane. He further hypothesized that syphilitic Tabes Dorsalis might have a "spinal cord only" neurodegenerative equivalent In borreliosis, namely Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease). He hypothesized that syphilitic Temporal arteritis might have a Borrelia equivalent in Temporal arteritis of unknown cause. In addition to the ongoing Alzheimer's studies, which would occupy the remainder of his research career, Alan made basic new observations in pathobiology. He was the first to publish evidence for a cystic form of Bb, granular forms of Bb, and cell wall deficient forms. Although officially retired now, Dr. MacDonald has started a research collaboration with Dr. Eva Sapi of University of New Haven.