International Lyme And Associated Diseases Society
Leaders in Lyme Disease Education and Training

Speaker: Richard A. Van Konynenburg, PhD

Saturday, Nov. 3, 2012

Review of Oxidative Stress

Rich Van Konynenburg's formal education was in engineering and the applied physical sciences. He received a Ph.D. degree from the University of California--Davis in 1974. He served as an officer in the U.S. Army Corps of Engineers for two years, and worked for the University of California at Lawrence Livermore National Laboratory for 30 years, doing research and development in nuclear materials and technology.

He has studied myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) for the past 16 years. In 2007, he proposed a hypothesis for the pathogenesis and pathophysiology of CFS, called the "Glutathione Depletion—Methylation Cycle Block" hypothesis. Based on this hypothesis, he has been encouraging the application of methylation cycle treatment (originally developed to treat autism), to the treatment of ME/CFS. This type of treatment was found in a clinical study with Neil Nathan, M.D., to provide significant benefit to about two-thirds of the patients who participated, and its use is growing in the ME/CFS community internationally. In 2009, Rich proposed a link between Lyme disease and ME/CFS involving oxidative stress and the depletion of glutathione.